A ROLE FOR GENE-ENVIRONMENT INTERACTIONS IN AUTISM SPECTRUM DISORDER IS SUPPORTED BY VARIANTS IN GENES REGULATING THE EFFECTS OF EXPOSURE TO XENOBIOTICS

A Role for Gene-Environment Interactions in Autism Spectrum Disorder Is Supported by Variants in Genes Regulating the Effects of Exposure to Xenobiotics

Heritability estimates support the contribution of genetics and the environment to the etiology of Autism Spectrum Disorder (ASD), but a role for gene-environment interactions is insufficiently explored.Genes involved in detoxification pathways and physiological permeability barriers (e.g., blood-brain barrier, placenta and respiratory airways), wh

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Thoracic aortic size in Brazilian smokers: measures using low-dose chest computed tomography anatomical and epidemiological assessment

OBJECTIVES: Thoracic aortic aneurysms (TAAs) represent one-third of the hospitalizations for aortic diseases.The prevalence rate depends on the definition of the normal size of the aorta, which is quite variable, depending on the population studied.The aim of this study was to evaluate the characteristics of the thoracic aorta Upright Freezer of Br

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Thioredoxin peroxidase secreted by Echinococcus granulosus (sensu stricto) promotes the alternative activation of macrophages via PI3K/AKT/mTOR pathway

Abstract Background Larvae of Echinococcus granulosus (sensu lato) dwell in host organs for a long time but elicit only a mild inflammatory response, which indicates that the resolution of host inflammation is necessary for parasite survival.The recruitment of alternatively activated macrophages (AAMs) has been observed in a variety of helminth inf

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